AB1547 SHEAR-WAVE ELASTOGRAPHIC ULTRASOUND OF SECOND METACARPOPHALANGEAL IN SYNOVIUM OF RHEUMATOID ARTHRITIS

Background Shear wave elastography (SWE) is a recent development in ultrasound (SW-EUS). SWE allows quantitative evaluation of the elastic properties and stiffness tissue serves as an adjunct to conventional US techniques. There hypothesis that rheumatoid arthritis (RA) patients would have softer synovium than controls this could be quantified with slower SWV. We also assessed whether SWV varied disease activity. The challenge application SW-EUS there are multiple bone interfaces fluid synovial joint which gave rise increased chances fallacious values. Objectives To perform analysis second metacarpophalangeal (2MCP) RA controls. Determine if correlation between Methods A prospective case-control study. Fifteen were consecutively recruited matched ten Participants underwent clinical assessment, blood sampling, grey scale (GSUS), power Doppler MCP joints 2, on dominant hand. Ultrasound examination was undertaken by two musculoskeletal trained sonographers. Both blinded patient diagnosis, results, pathology previous findings. performed first, followed GSUS PDUS. Scanning carried out using linear array transducer at 6-18 mHz frequency Virtual TouchTM software. 2 hand scanned resting 20 degrees flexion. dorsal aspect imaged three planes; longitudinal midline (DLM), radial (30° offset from midline, DLR) ulnar (30% DLU). Results Average age 50. Mean activity (DAS28-ESR) moderate 3.85. Patients (Figure 1) had lower mean (5.27 m/s vs 12.00 p< 0.001) (figure 2); maximum (6.88 vs. 12.80 P <0.001). EM (RA 168.17 kPa, 437.81 kPa). low (7.48 m/s); (168.17 high (2.61 (25.45 kPa) Negative Pearson’s coefficients (PCC) observed markers including graded thickness (PCC = -0.67, p 0.03) ESR -0.45, 0.085). Figure 1. elastogram Color synovium, shows shear-wave velocity (SWV) (mean, 5.27 m/s) patient. data collected Vinno G86 scanner L16–6 MHz 2. healthy control Conclusion This first pilot study Latin America synovium. modulus significantly negative thickening assessing RA. Further warranted confirm role diagnosing References [1]Taljanovic MS, Gimber LH, Becker GW, Latt LD, Klauser AS, Melville DM, et al. Shear-wave elastography: basic physics applications. Radiographics. 2017; 37:855–870. [2]Chandel K, Prakash M, Sinha A, Sharma Chouhan DK, Sandhu MS. Role Wave Elastography Synovium Differentiate Rheumatoid Tubercular Arthritis. J Med Ultrasound. 2021 Dec 27;30(1):30-35. doi: 10.4103/jmu.jmu_80_21. PMID: 35465588; PMCID: PMC9030352 Acknowledgements: NIL. Disclosure Interests None Declared.